A man used to vicissitudes is not easily dejected.饱经沧桑,不易沮丧.The city has been through many vicissitudes.这个城市经历了多次兴衰.Whatever the vicissitudes of her past life, Jill now seems to have come through.不管过去经历了什么坎坷，吉尔现在似乎都已经挺过来...
It causes blindness or serious loss of vision.这能导致失明或视力严重受损。Early diagnosis and treatment can usually prevent blindness.早期的诊断和治疗通常可以预防失明。I have long since come to terms with my blindness.我早就安于自己的失明了....